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No standard dose reduction exists for chloramphenicol in liver impairment, and the dose should be adjusted according to measured plasma concentrations.

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Consideration should be given to official guidance on the appropriate use of antibacterial agentsEscherichia coliHaemophilus influenzaeStaphylococcus aureusStreptococcus haemolyticusMorax-AxenfeldKlebsiella/Enterobacter species and others.

PREGNANCYThere are no adequate studies done on chloramphenicol to determine safe and effective use in pregnant women.

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